AN UNBIASED VIEW OF PALMITOYLETHANOLAMIDE

2015). These research, taken jointly, recommend that, Even though a direct activation of GPR55 or PPAR‐α happens, PEA can make its anti‐inflammatory action inside the intestine also by way of oblique activation of CB1 and CB2 receptors, most likely on account of the power of the compound to potentiate the action of endocannabinoids at these re

PEA shields towards bacterial infection by way of innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA at a dose of 0.1 mg/kg physique fat extended survival charge and lessened neuro-inflammation in an aged murine bacterial meningitis design, in the absence of antibiotics [forty two].Just about the most widely studied